Nuclear medicine imaging of endocarditis.
Identifieur interne : 003B98 ( Main/Exploration ); précédent : 003B97; suivant : 003B99Nuclear medicine imaging of endocarditis.
Auteurs : RBID : pubmed:10230285English descriptors
- KwdEn :
- MESH :
- chemical , diagnostic use : Antibodies, Monoclonal, Radiopharmaceuticals.
- radionuclide imaging : Endocarditis, Bacterial, Heart.
- Humans, Isotope Labeling, Leukocytes, Tomography, Emission-Computed, Single-Photon.
Abstract
Infective endocarditis is a serious disease which requires early diagnosis and adequate therapy. Echocardiography plays a key role in diagnosis and follow-up. Subacute infective endocarditis, however, is often difficult to prove echocardiographically due to its more subtle morphological changes. Also, echocardiography cannot reliably differentiate florid vegetations from residual structural changes of the affected valves in cured patients. Therefore, scintigraphy of infection and inflammation, a functional imaging procedure, has been investigated as a complementary tool in diagnosis and follow-up of infective endocarditis. So far, results obtained with Gallium-67 scintigraphy are not convincing, although an improvement by using modern acquisition techniques seems possible. Scintigraphy with Indium-111 labelled leukocytes has an unacceptably low sensitivity, which is probably due to the small number of cells involved and unfavourable imaging characteristics of 111In-Technetium-99m labelled leukocytes have been investigated in few patients, so final judgement is not yet possible. SPECT imaging might enhance the detectability of diseased heart valves. Immunoscintigraphy with the 99mTc labelled antigranulocyte antibody in SPECT technique is complementary to echocardiography and seems to assess the floridity of the underlying inflammatory process. The combined use of both imaging modalities allows detection of virtually all cases of subacute infective endocarditis. SPECT immunoscintigraphy with the antigranulocyte antibody seems useful in doubtful cases of infective endocarditis, especially, if echocardiography is non-diagnostic and valve pathology pre-existing. The method may be used for follow-up and monitoring antibiotic therapy.
PubMed: 10230285
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nuclear medicine imaging of endocarditis.</title><author><name sortKey="Ivancevi, V" uniqKey="Ivancevi V">V Ivancević</name><affiliation wicri:level="3"><nlm:affiliation>Clinic for Nuclear Medicine, University Hospital Charité, Humboldt University, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic for Nuclear Medicine, University Hospital Charité, Humboldt University, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Munz, D L" uniqKey="Munz D">D L Munz</name></author></titleStmt><publicationStmt><date when="1999">1999</date><idno type="RBID">pubmed:10230285</idno><idno type="pmid">10230285</idno><idno type="wicri:Area/Main/Corpus">003E93</idno><idno type="wicri:Area/Main/Curation">003E93</idno><idno type="wicri:Area/Main/Exploration">003B98</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (diagnostic use)</term><term>Endocarditis, Bacterial (radionuclide imaging)</term><term>Heart (radionuclide imaging)</term><term>Humans</term><term>Isotope Labeling</term><term>Leukocytes</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Endocarditis, Bacterial</term><term>Heart</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Isotope Labeling</term><term>Leukocytes</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infective endocarditis is a serious disease which requires early diagnosis and adequate therapy. Echocardiography plays a key role in diagnosis and follow-up. Subacute infective endocarditis, however, is often difficult to prove echocardiographically due to its more subtle morphological changes. Also, echocardiography cannot reliably differentiate florid vegetations from residual structural changes of the affected valves in cured patients. Therefore, scintigraphy of infection and inflammation, a functional imaging procedure, has been investigated as a complementary tool in diagnosis and follow-up of infective endocarditis. So far, results obtained with Gallium-67 scintigraphy are not convincing, although an improvement by using modern acquisition techniques seems possible. Scintigraphy with Indium-111 labelled leukocytes has an unacceptably low sensitivity, which is probably due to the small number of cells involved and unfavourable imaging characteristics of 111In-Technetium-99m labelled leukocytes have been investigated in few patients, so final judgement is not yet possible. SPECT imaging might enhance the detectability of diseased heart valves. Immunoscintigraphy with the 99mTc labelled antigranulocyte antibody in SPECT technique is complementary to echocardiography and seems to assess the floridity of the underlying inflammatory process. The combined use of both imaging modalities allows detection of virtually all cases of subacute infective endocarditis. SPECT immunoscintigraphy with the antigranulocyte antibody seems useful in doubtful cases of infective endocarditis, especially, if echocardiography is non-diagnostic and valve pathology pre-existing. The method may be used for follow-up and monitoring antibiotic therapy.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">10230285</PMID><DateCreated><Year>1999</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>1999</Year><Month>06</Month><Day>18</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1125-0135</ISSN><JournalIssue CitedMedium="Print"><Volume>43</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Mar</Month></PubDate></JournalIssue><Title>The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR)</Title><ISOAbbreviation>Q J Nucl Med</ISOAbbreviation></Journal><ArticleTitle>Nuclear medicine imaging of endocarditis.</ArticleTitle><Pagination><MedlinePgn>93-9</MedlinePgn></Pagination><Abstract><AbstractText>Infective endocarditis is a serious disease which requires early diagnosis and adequate therapy. Echocardiography plays a key role in diagnosis and follow-up. Subacute infective endocarditis, however, is often difficult to prove echocardiographically due to its more subtle morphological changes. Also, echocardiography cannot reliably differentiate florid vegetations from residual structural changes of the affected valves in cured patients. Therefore, scintigraphy of infection and inflammation, a functional imaging procedure, has been investigated as a complementary tool in diagnosis and follow-up of infective endocarditis. So far, results obtained with Gallium-67 scintigraphy are not convincing, although an improvement by using modern acquisition techniques seems possible. Scintigraphy with Indium-111 labelled leukocytes has an unacceptably low sensitivity, which is probably due to the small number of cells involved and unfavourable imaging characteristics of 111In-Technetium-99m labelled leukocytes have been investigated in few patients, so final judgement is not yet possible. SPECT imaging might enhance the detectability of diseased heart valves. Immunoscintigraphy with the 99mTc labelled antigranulocyte antibody in SPECT technique is complementary to echocardiography and seems to assess the floridity of the underlying inflammatory process. The combined use of both imaging modalities allows detection of virtually all cases of subacute infective endocarditis. SPECT immunoscintigraphy with the antigranulocyte antibody seems useful in doubtful cases of infective endocarditis, especially, if echocardiography is non-diagnostic and valve pathology pre-existing. The method may be used for follow-up and monitoring antibiotic therapy.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ivancević</LastName><ForeName>V</ForeName><Initials>V</Initials><Affiliation>Clinic for Nuclear Medicine, University Hospital Charité, Humboldt University, Berlin, Germany.</Affiliation></Author><Author ValidYN="Y"><LastName>Munz</LastName><ForeName>D L</ForeName><Initials>DL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType><PublicationType>Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ITALY</Country><MedlineTA>Q J Nucl Med</MedlineTA><NlmUniqueID>9512274</NlmUniqueID><ISSNLinking>1125-0135</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Antibodies, Monoclonal</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Endocarditis, Bacterial</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Heart</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Isotope Labeling</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Leukocytes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>77</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>5</Month><Day>7</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>5</Month><Day>7</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>5</Month><Day>7</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10230285</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B98 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B98 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:10230285
|texte= Nuclear medicine imaging of endocarditis.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10230285" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |